I finally got one of my creatures above 151M gene strength since that would push a lv10 sigil above 2.14B gene strength.
I’m pretty sure lv 132M enemies with >2.14B gene strength shouldn’t die with 10B damage dealt to them.
The gene strength displays as negative approx -2.14B.
I haven’t reached point where levels exceed 2.14B yet. So I don’t know if those will go negative or not.