Debuffs added before the spell is cast

I play as a defiler and use Pandemonium Fever, Reign of Chaos and Grim Ailment to give opponents debuffs before the first move.

The debuffs that are added by Grim Ailment, however, have the opponents right at the start of the fight, even before Affliction is cast. Even if the creature with Pandemonium Fever doesn’t even get to cast Affliction, for example because of the Supersonic Trait.