The amount of key presses to craft 1 pill of upgrading is 7.
To feed to nether is 5 per pill.
Crafting 300 of them would take 2100 presses for just buying the pills.
Feeding 300 would take 1500 presses.
Not counting buying the crafting items necessary for crafting the pills.
A dialog box asking how many you would like to buy / craft / feed would save on the amount of key presses.